In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Hannah Went, co-founder of TrueAge, a leading omics age company. They discuss the significance of epigenetics in understanding biological age, the predictive power of various aging clocks, and the advancements in measuring biological age through multi-omics approaches. The conversation also covers the impact of interventions like caloric restriction on aging metrics, the Dunedin Pace as a new metric for biological aging, and the complexity of aging as a multifactorial process. Went shares insights into the future of epigenetic research and the importance of actionable insights for health optimization.
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Listen to this episode here:
Show notes
Takeaways
- Epigenetic markers can predict chronological age with high accuracy.
- GrimAge is a new clock that estimates mortality risk.
- Multi-omics approaches provide a comprehensive view of aging.
- Caloric restriction significantly impacts biological age.
- Dunedin Pace measures the rate of biological aging.
- Aging is a complex, multifactorial process.
- Understanding what tests do not measure is crucial.
- New biomarkers for aging are being developed and validated.
Chapters
00:00 Introduction to Omics Age and TrueAge
04:12 The Evolution of Epigenetic Clocks
07:55 Integrating Lifestyle Factors in Omics Age Testing
10:14 Predicting Disease Risk and Mortality with Omics Age
13:27 Reversing Biological Age with Interventions
16:42 Actionable Insights from Omics Age Testing
26:30 Exploring the Impact of Caloric Restriction on Aging
29:08 Understanding the Dunedin Pace as a Measure of Biological Aging
33:32 The Complexity of Aging and the Limitations of Single Metrics
35:24 Epigenetic Biomarker Proxies: A Comprehensive Approach to Aging
43:59 Cell Reprogramming and its Implications for Aging
49:24 Goodbye
Learn more about TruAge and/or contact them:
Email: hannah@trudiagnostic.com
Website: https://www.trudiagnostic.com/
Facebook: https://www.facebook.com/TruDiagnostic/
Instagram: https://www.instagram.com/trudiagnosticofficial/
X: https://x.com/TruDiagnostic
YouTube: https://www.youtube.com/c/trudiagnostic
TikTok: https://www.tiktok.com/@trudiagnostic?is_from_webapp=1&sender_device=pc
LinkedIn: https://www.linkedin.com/company/trudiagnostic/
Reach out to us!
Email: podcast@gladdenlongevity.com
