Gladden Longevity

Customize your Nootropics! – Episode 175

From sick to superhuman? Join Dr. Jeffrey Gladden and Mark Noots in this episode of the Gladden Longevity Podcast. Mark Effinger, also known as Mr. Noots, has had a lifelong passion for neuroscience. Tragedy struck when he faced a health crisis and lost his wife to a painkiller overdose. Determined to make a difference, he founded Nootopia and now serves as the company’s Chief Product Officer. With the help of the dedicated team at BiOptimizers and Nootopia, Mark is on a mission to create high-performance, experiential nutritional supplements that can reverse the effects of addiction and disease. Through his tireless efforts, Mark hopes to address these human conditions as effectively and healthily as possible, and he is committed to positively impacting the world and improving the lives of others. Thisepisode discusses sleep, biochemistry and brain optimization, cognitive performance, and Nootropics.  They also delve deeper into why longevity without health is folly, about why amplifying cognitive function and state optimization is the key to effective longevity, health, and happiness, and how sleep is the world’s most powerful stimulant. Listen to find out more. 

Listen to this episode to learn about making 100 the new 30, and Living Young for a Lifetime!

Discount code: 

Gladden10 (get a 10% discount from your purchase at

Show Notes:

Dr. Gladden welcomes everyone to the Age Hackers Podcast powered by Gladden Longevity. (0:40) 

Mark shares his history and what he did in the past, including bodybuilding and mountain climbing. (2:37) 

Mark explains how he was diagnosed with hypothyroid dysfunction. (3:47) 

Dr. Gladden notes that Mark had a lot of detox issues. (5:44) 

Mark gives an example of diffusing the room, bringing humor in, and signing a deal. (7:12) 

Mark speaks about his experience of creating brainstorming and innovation software. (9:43) 

Dr. Gladden points out that exercise is another strong nootropic. (11:44) 

Mark says that his currency is the ability to think through big problems. (14:25) 

Mark discloses that PQQ was one of his early favorites in increasing ATP. (19:42) 

Mark states that the brain shrinks a bit during the sleep cycle. (21:00) 

Dr. Gladden notes that optimal performance is not just about cognitive ability but the ability to go into a state. (29:27) 

Mark adds that we play our best in a flow state. (35:56) 

Mark implies that people are not just interested in cognitive performance but in having joy in what they are doing. (38:26) 

 Dr. Gladden notes that not everything works for everybody, and some things work better for some than for others. (47:08) 

Mark explains how they use a free app to get and process data. (49:08) 

Dr. Gladden asks Mark to share how he administers his solution to people. (53:21) 

Dr. Gladden says it is unusual for nootropics companies to focus on areas that Mark focuses on. (57:03) 

Mark mentions some of the things he took before coming on the show. (1:00:27) 

Dr. Gladden emphasizes that society has normalized aging and decline (1:03:15) 

Dr. Gladden says reframing the question is one thing that he thinks should be considered and looked into in the longevity space. (1:05:27) 

Dr. Gladden expands on longevity as an abstract term. (1:07:11) 

Dr. Gladden talks about longevity as an exponential response to an exponential problem. (1:09:01) 

Mark speaks on the importance of ensuring you have a big purpose. (1:12:33) 

Mark mentions that his goal is to make a monumental impact on every life he touches. (1:14:25) 

Steve thanks listeners for listening to this episode. 

To learn more about Mark (Mr. Noots) and Nootopia, check out the following: 

Instagram: @nootopiabrain 



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